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Clinical study participants who took Lubrizol’s microencapsulated magnesium had significantly higher blood concentrations than those who took a variety of chelates.
February 24, 2025
By: Mike Montemarano
Associate Editor, Nutraceuticals World
Magshape, a microencapsulated magnesium ingredient marketed by Lubrizol Nutraceuticals, appeared to be more bioavailable than chelated forms of magnesium common in dietary supplements, a new human clinical study found. Additionally, Magshape supplementation wasn’t associated with any of the side effects commonly associated with magnesium consumption.
Absorption rates of magnesium can be as low as 10%, depending on the type of magnesium used and other formulation factors, according to Lubrizol. Once absorbed, 60% of magnesium is stored in the bones, 20% in muscles, and 20% in soft tissues.
“Blood magnesium levels are a direct reflection of intestinal absorption efficiency and formed the basis of our investigation into the absorption dynamics of our proprietary microencapsulation technology,” said Alan Connolly, PhD, R&D manager of Lubrizol Nutraceuticals. “Magshape was designed to benefit individuals seeking to maintain adequate magnesium levels for overall health and well-being while also supporting improved post-exercise muscle recovery or improved sleep patterns.”
In the double-blind, randomized, crossover clinical study, which was published in Nutrients, 40 healthy men and women were administered a variety of magnesium supplements. The study assessed blood concentrations of magnesium in participants who took either Magshape, or other magnesium sources like magnesium oxide, magnesium citrate, and magnesium bisglycinate, all administered at doses of 375 mg. Blood samples were taken at baseline, and again at 1, 4, and 6 hours after intake.
The authors found that Magshape was significantly more bioavailable than non-microencapsulated magnesium forms, with sustained levels for up to six hours post-intake. Participants also reported fewer adverse effects, including reduced bowel activity and gastric “heaviness” with Magshape capsules compared to the comparison products. Altogether, the study introduced Magshape as a “bioavailable and well-tolerated alternative” to other forms of magnesium on the market.
“These findings underscore the potential of Magshape microcapsules to transform magnesium supplementation into a routine that is much easier to swallow and more beneficial,” said Isabel Gomez, marketing manager of Lubrizol Nutraceuticals. “The enhanced absorption and reduced side effects observed in our study can be attributed to the innovative technologies employed to produce the Magshape microcapsules.”
Microencapsulation of magnesium, according to Lubrizol Nutraceuticals, can help the nutrient gradually assimilate throughout the entire digestive system, ensuring more gets into the bloodstream to replenish magnesium levels in the body’s cells and tissues.
Magshape can be formulated into small tablets, as well as 1.5 mg quick-dissolving powder sachets for melt-in-the-mouth consumption.
“This innovative approach to magnesium supplementation not only helps to increase magnesium levels but to maintain them over time,” said Teresa Negra, new business development manager for nutraceuticals and food. “Together with its high gastric tolerability, this makes Magshape an ideal, science-backed solution for those seeking to gain the long-term health benefits associated with having consistently adequate magnesium levels.”
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